منابع مشابه
Modeling Kick-Kill Strategies toward HIV Cure
Although combinatorial antiretroviral therapy (cART) potently suppresses the virus, a sterile or functional cure still remains one of the greatest therapeutic challenges worldwide. Reservoirs are infected cells that can maintain HIV persistence for several years in patients with optimal cART, which is a leading obstacle to eradicate the virus. Despite the significant progress that has been made...
متن کاملProgress toward an HIV vaccine.
The development of an HIV vaccine is proving to be an unprecedented challenge. The difficulty in creating this vaccine arises from the enormous genetic variation of the virus and the unusual importance of cytotoxic T lymphocytes (CTL) in controlling its spread. Whereas traditional vaccine strategies are unlikely to confer safe and effective HIV protection, novel strategies for eliciting CTL hav...
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Epidermolysis bullosa, a group of heritable blistering disorders, shows extensive phenotypic variability due to mutations in as many as 20 distinct genes. There is no cure for this devastating group of disorders; however, a number of preclinical developments show promise, and some approaches have already reached the stage of early clinical trials. Dystrophic Epidermolysis Bullosa Research Assoc...
متن کاملTowards a cure for HIV--are we making progress?
Until recently, no-one dared to discuss a cure when it came to HIV. There had been a general consensus among experts that the best we would ever achieve would be durable control of the infection with antiretroviral therapy (ART). And, in this regard, we have been tremendously successful. ART is often given as only one tablet a day with minimal toxicity, leads to normal life expectancy, and redu...
متن کاملTargeting the Brain Reservoirs: Toward an HIV Cure
One of the top research priorities of the international AIDS society by the action "Towards an HIV Cure" is the purge or the decrease of the pool of all latently infected cells. This strategy is based on reactivation of latently reservoirs (the shock) followed by an intensifying combination antiretroviral therapy (cART) to kill them (the kill). The central nervous system (CNS) has potential lat...
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ژورنال
عنوان ژورنال: Journal of Virus Eradication
سال: 2016
ISSN: 2055-6640
DOI: 10.1016/s2055-6640(20)31238-3